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Sodium Carbonate → HCID 44540690, 화합물

HRID 1616001
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HRID 1616001 반응식
Br[C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][N:8]2[CH2:11][CH3:12])=[C:4]([NH:13][C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[N:17]=2)=[O:15])[CH:3]=1.CC1(C)C(C)(C)OB([C:31]2[CH:39]=[CH:38][CH:37]=[C:36]3[C:32]=2[CH:33]=[CH:34][NH:35]3)O1.C(=O)([O-])[O-].[Na+].[Na+]>C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2].O1CCOCC1>[CH2:11]([N:8]1[C:9]2[C:5](=[C:4]([NH:13][C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[N:17]=3)=[O:15])[CH:3]=[C:2]([C:31]3[CH:39]=[CH:38][CH:37]=[C:36]4[C:32]=3[CH:33]=[CH:34][NH:35]4)[CH:10]=2)[CH:6]=[N:7]1)[CH3:12]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 10340Sodium CarbonateHCID 113224711H-Indole-4-boronic acid, pinacol esterHCID 58268025HCID 58268025, 화합물

생성물 1

HCID 44540690HCID 44540690, 화합물수율 45.2%

시약·촉매·용매 2

HCID 44119782Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)촉매
HCID 31275
1,4-Dioxane
용매

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온도
150 °C

실험 절차

N-(6-Bromo-1-ethyl-1H-indazol-4-yl)-6-methyl-2-pyridinecarboxamide (50 mg, 0.14 mmol), 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole (available from Frontier Scientific, 38 mg, 0.17 mmol), Pd(dppf)Cl2 (23 mg), aqueous sodium carbonate (2M, 0.272 ml) and 1,4-dioxane (2 ml) were combined and heated at 150° C. for 10 mins under microwave conditions. The reaction was extracted into DCM (2×20 ml) and the combined organic layers were evaporated to dryness, before purification by Mass Directed Automated Preparative HPLC (Method B). Pure fractions were evaporated to give the title compound (25 mg).

후처리

  1. extractionThe reaction was extracted into DCM (2×20 ml)
  2. customthe combined organic layers were evaporated to dryness, before purification by Mass Directed Automated Preparative HPLC (Method B)
  3. customPure fractions were evaporated

출처 및 근거

ORD 기록
ord-8afcf81c800b4dc8b2bbb2a744e9423d
출처 데이터셋
uspto-grants-2014_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08765743B2

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