참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Urea | HCID 1176 | — |
| 반응물 | 2-Aminoterephthalic acid | HCID 2724822 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2,4-Dihydroxyquinazoline-7-carboxylic acid | HCID 19604289 | 92% |
반응 단계
Into a round bottom flask was added 2-aminoterephthalic acid (0.83 g, 4.6 mmol) and urea (2.75 g, 45.8 mmol). The reaction mixture was heated to 160° C. and stirred overnight. The mixture was cooled to rt, water added and the solid was filtered. The solid was then washed with acetic acid to afford 2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylic acid (0.87 g, 92%). LC-MS: (FA) ES+ 207.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08765773B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_07 |
|---|
| ORD ID | ord-98a84cca8c8c481cb09e50c3327bab43 |
|---|
| 출처 메모 | uspto-grants-2014_07 |
|---|
