tert-Butyl 3-(bromomethyl)phenylcarbamate → Methyl 2-{3-[(tert-butoxycarbonyl)amino]benzyl}-1-oxo-1,2-dihydroisoquinoline-7-carboxylate

HRID 1616168

반응식

HRID 1616168 반응식
[C:1]([O:5][C:6](=[O:16])[NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH2:14]Br)[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[O:17]=[C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[C:25]([C:28]([O:30][CH3:31])=[O:29])[CH:26]=2)[CH:21]=[CH:20][NH:19]1>>[C:1]([O:5][C:6]([NH:7][C:8]1[CH:9]=[C:10]([CH:11]=[CH:12][CH:13]=1)[CH2:14][N:19]1[CH:20]=[CH:21][C:22]2[C:27](=[CH:26][C:25]([C:28]([O:30][CH3:31])=[O:29])=[CH:24][CH:23]=2)[C:18]1=[O:17])=[O:16])([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 14523558tert-Butyl 3-(bromomethyl)phenylcarbamateHCID 60075037Methyl 1-oxo-1,2-dihydroisoquinoline-7-carboxylate

생성물 1

HCID 67281970Methyl 2-{3-[(tert-butoxycarbonyl)amino]benzyl}-1-oxo-1,2-dihydroisoquinoline-7-carboxylate

실험 절차

The title compound was prepared from tert-butyl[3-(bromomethyl)phenyl]carbamate (0.42 g, 1.48 mmol) and methyl 1-oxo-1,2-dihydroisoquinoline-7-carboxylate (0.20 g, 0.98 mmol) following the procedure outlined in Example 3, step 1 (0.31 g, 77%). LC-MS: (FA) ES+ 409.

출처 및 근거

ORD 기록
ord-b976d0cceef543a4b5134626dce4738c
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765773B2

연결된 노트

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