1-Bromo-4-chlorobutane → 9-(4-Chlorobutyl)-2-(cyclopentyloxy)-8-(methyloxy)-9H-purin-6-amine
반응식
[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:14]([O:15][CH3:16])=[N:13][C:12]2[C:7]1=[N:8][C:9]([O:18][C@@H:19]([CH3:22])[CH2:20][CH3:21])=[N:10][C:11]=2[NH2:17].F[C:24](F)(F)C(O)=O.C1(OC2NC(N)=C3C(N=2)=NC(OC)=N3)CCCC1.BrCCCCCl>>[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:14]([O:15][CH3:16])=[N:13][C:12]2[C:7]1=[N:8][C:9]([O:18][CH:19]1[CH2:22][CH2:24][CH2:21][CH2:20]1)=[N:10][C:11]=2[NH2:17]참가 물질
4
실험 절차
Prepared similarly to Intermediate 44 from 2-(cyclopentyloxy)-8-(methyloxy) -1H-purin-6-amine trifluoroacetate and 1-bromo-4-chlorobutane.
출처 및 근거
- ORD 기록
- ord-f095fd52ae1444bf8c75319b2a130e80
- 출처 데이터셋
- uspto-grants-2014_07
- 특허 번호
- US08765772B2
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