Hydrazine → N-aminobenzenecarbothioamide

HRID 1616552

반응식

HRID 1616552 반응식
COC(=O)C[S:5][C:6](=S)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[NH2:15][NH2:16]>C(O)C>[C:6]([NH:15][NH2:16])(=[S:5])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 71356278Methyl 2-((phenylcarbonothioyl)thio)acetate

생성물 1

HCID 3361911N-aminobenzenecarbothioamide수율 94%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Add a solution of thiobenzoylsulfanylacetic acid methyl ester (1.9 g, 8.4 mmol) in ethanol (30 mL) to a solution of anhydrous hydrazine (1 mL) at room temperature under nitrogen and stir for 2 hours. Then add water (20 mL) and remove the solvent under reduced pressure. Dissolve the residue in ethyl acetate (300 mL), wash with water (200 mL) and brine (200 mL), and dry over magnesium sulfate. Remove the solvent under reduced pressure to provide thiobenzoic acid hydrazide (1.2 g, 94%).

후처리

  1. customThen add water (20 mL) and remove the solvent under reduced pressure
  2. dissolutionDissolve the residue in ethyl acetate (300 mL)
  3. washwash with water (200 mL) and brine (200 mL)
  4. dry with materialdry over magnesium sulfate
  5. customRemove the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-ba5d82d32f0e4da5af7db1d74368ee13
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765796B2

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