m-Fluorobenzenethiol → 7-[(3-Fluorophenyl)sulfonyl]-2'-methyl-3,4,4',5'-tetrahydro-2H-spiro[1-benzofuro[2,3-c]pyridine-1,3'-furan]

HRID 1616872

반응식

HRID 1616872 반응식
[F:1][C:2]1[CH:3]=[C:4]([S:8]([C:11]2[CH:16]=[CH:15][C:14]3[C:17]4[CH2:28][CH2:27][NH:26][C:20]5([CH2:25][CH2:24]C[O:22][CH2:21]5)[C:18]=4[O:19][C:13]=3[CH:12]=2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.F[C:30]1C=C(S)C=CC=1.IC1C=CC2C3CCNC4(CCOC4C)C=3OC=2C=1>>[F:1][C:2]1[CH:3]=[C:4]([S:8]([C:11]2[CH:16]=[CH:15][C:14]3[C:17]4[CH2:28][CH2:27][NH:26][C:20]5([CH2:25][CH2:24][O:22][CH:21]5[CH3:30])[C:18]=4[O:19][C:13]=3[CH:12]=2)(=[O:9])=[O:10])[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 75710m-FluorobenzenethiolHCID 533276117-[(3-fluorophenyl)sulfonyl]-3,4,5',6'-tetrahydro-2H,4'H-spiro[1-benzofuro[2,3-c]pyridine-1,3'-pyran]HCID 673249457-Iodo-2'-methyl-3,4,4',5'-tetrahydro-2H-spiro[1-benzofuro[2,3-c]pyridine-1,3'-furan]

생성물 1

HCID 533276147-[(3-Fluorophenyl)sulfonyl]-2'-methyl-3,4,4',5'-tetrahydro-2H-spiro[1-benzofuro[2,3-c]pyridine-1,3'-furan]

실험 절차

Prepared as described for 7-[(3-fluorophenyl)sulfonyl]-3,4,5′,6′-tetrahydro-2H,4′H-spiro[1-benzofuro[2,3-c]pyridine-1,3′-pyran] (Example 22) starting from 3-fluorobenzenethiol and 7-iodo-2′-methyl-3,4,4′,5′-tetrahydro-2H-spiro[1-benzofuro[2,3-c]pyridine-1,3′-furan].

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-141888000b1d404995dd66c93126337c
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765779B2

연결된 노트

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