참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | 2-Bromopropane | HCID 6358 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 5-Iodobenzene-1,3-diol | HCID 616755 | — |
| 생성물 | 3-Iodo-5-isopropoxyphenol | HCID 67325346 | 37.8% |
반응 단계
A mixture of 5-Iodo-benzene-1,3-diol (2 g, 8 mmol), 2-bromopropane (0.88 mL, 9.3 mmol) and potassium carbonate (1.3 g, 9.3 mmol) in DMF (15 mL, 190 mmol) was stirred at 65° C. After 18 h, the mixture was cooled to RT and the solvent was evaporated. The residue was dissolved in DCM, washed with water and brine. The solvent was evaporated and the residue was purified on silica gel using an ISCO instrument and eluting with hexanes:EtOAc (4:1) to afford the title product (841 mg). MS m/z: 279 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08765779B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_07 |
|---|
| ORD ID | ord-26b89431d05b4ac4a031f081e8aa30ca |
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| 출처 메모 | uspto-grants-2014_07 |
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