Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1617174생성일: 2026년 10월 26일
(2S)-2-aminopentan-1-ol → (S)-2-(4-((2-Amino-4-(1-hydroxypentan-2-ylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxyphenyl)acetonitrile
https://huagongshe.com/reaction/1617174
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | (2S)-2-aminopentan-1-ol | HCID 6951248 | — |
| 반응물 | 2-(4-((2-Amino-4-chloro-6-methylpyrimidin-5-yl)methyl)-3-methoxyphenyl)acetonitrile | HCID 86633402 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | (S)-2-(4-((2-Amino-4-(1-hydroxypentan-2-ylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxyphenyl)acetonitrile | HCID 68955240 | — |
반응 단계
(S)-2-Aminopentan-1-ol (0.136 g) was added to a solution of the product from step (iii) in NMP (2 mL). The resulting mixture was stirred at 140° C. for 50 h then diluted with EtOAc and washed with saturated NaHCO3 solution and saturated brine. The organic phase was dried, filtered and evaporated. The crude product was purified by column chromatography, elution gradient 5 to 10% MeOH in DCM to give the subtitle compound, 0.095 g.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08765939B2 |
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| 출처 데이터셋 | uspto-grants-2014_07 |
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| ORD ID | ord-6913b3a48b284ac8ad14246b53620be3 |
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| 출처 메모 | uspto-grants-2014_07 |
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