(S)-3-aminoheptan-1-ol → (S)-2-(4-((2-Amino-4-(1-hydroxyheptan-3-ylamino)-6-methylpyrimidin-5-yl)methyl)-3-fluorophenyl)acetonitrile

참여 물질

역할	이름	HCID	투입량
반응물	(S)-3-aminoheptan-1-ol	HCID 55290391	—
반응물	2-(4-((2-Amino-4-chloro-6-methylpyrimidin-5-yl)methyl)-3-fluorophenyl)acetonitrile	HCID 86633405	—
용매	Water	HCID 962	—
용매	N-methyl-2-pyrrolidone	HCID 13387	—
생성물	(S)-2-(4-((2-Amino-4-(1-hydroxyheptan-3-ylamino)-6-methylpyrimidin-5-yl)methyl)-3-fluorophenyl)acetonitrile	HCID 68954091	—

반응 조건

온도	150 °C

반응 단계

(S)-3-Aminoheptan-1-ol (0.135 g) was added to a stirred solution of the product from step (iii) (0.12 g) in NMP (2 mL). The mixture was heated at 150° C. for 48 h, and then at 17° C. for a further 8 h. The mixture was allowed to cool, diluted with water (10 mL) and the aqueous extracted with EtOAc. The combined organic phase was dried and evaporated.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08765939B2
출처 데이터셋	uspto-grants-2014_07
ORD ID	ord-482afee383b24eb3a8b0beb918911005
출처 메모	uspto-grants-2014_07