Ethyl 2-(4-(benzyloxy)-2-methoxybenzylidene)-3-oxobutanoate → Ethyl 2-(4-hydroxy-2-methoxybenzyl)-3-oxobutanoate
반응식
C([O:8][C:9]1[CH:24]=[CH:23][C:12]([CH:13]=[C:14]([C:20](=[O:22])[CH3:21])[C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:11]([O:25][CH3:26])[CH:10]=1)C1C=CC=CC=1>CCOC(C)=O.[Pd]>[OH:8][C:9]1[CH:24]=[CH:23][C:12]([CH2:13][CH:14]([C:20](=[O:22])[CH3:21])[C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:11]([O:25][CH3:26])[CH:10]=1참가 물질
4
실험 절차
A mixture of the product from step (i) (40 g) and 5% Pd—C (3 g) in EtOAc were hydrogenated at 3 Bar for 48 h. The mixture was filtered through celite and evaporated under reduced pressure. The residue was purified by column chromatography eluting with 30% EtOAc/iso-hexane to afford the subtitle compound, 23.35 g.
후처리
- filtrationThe mixture was filtered through celite
- customevaporated under reduced pressure
- customThe residue was purified by column chromatography
- washeluting with 30% EtOAc/iso-hexane
출처 및 근거
- ORD 기록
- ord-690eaefada934d159f36b4f1461442e1
- 출처 데이터셋
- uspto-grants-2014_07
- 특허 번호
- US08765939B2
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