Salicylaldehyde → 2-[(2,6-Dibromophenyl)iminomethyl]phenol

HRID 16172

반응식

HRID 16172 반응식
[Br:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([Br:9])[C:3]=1[NH2:4].[CH:10](=O)[C:11]1[C:12](=[CH:14][CH:15]=[CH:16][CH:17]=1)[OH:13].C(N(CC)CC)C>C1(C)C=CC=CC=1.C1(C)C=CC(S(O)(=O)=O)=CC=1>[Br:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([Br:9])[C:3]=1[N:4]=[CH:10][C:11]1[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=1[OH:13]

참가 물질

6

반응물 3

HCID 6998SalicylaldehydeHCID 8471TriethylamineHCID 690982,6-Dibromoaniline

생성물 1

HCID 1363421452-[(2,6-Dibromophenyl)iminomethyl]phenol수율 109.8%

시약·촉매·용매 2

HCID 6101p-Toluenesulfonic acid촉매HCID 1140Toluene용매

실험 절차

A solution of 2,6-dibromoaniline (9 g, 35.9 mmol), salicylaldehyde (2.79 mL, 35.9 mmol) and p-toluenesulfonic acid (20 mg, 0.1 mmol) in toluene (180 mL) was heated to reflux in a Dean-Stark apparatus for 2 h. After adding some triethylamine the reaction mixture was evaporated resulting in crude compound 2-[(2,6-dibromophenyl)iminomethyl]phenol (14 g, 100%).

후처리

  1. temperatureto reflux in a Dean-Stark apparatus for 2 h
  2. customwas evaporated

출처 및 근거

ORD 기록
ord-857dd79300e54728be55fb33ddab7c0b
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737136B2

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