Tetrahydrofuran → 1(3H)-Isobenzofuranone, 6-fluoro-3-((1-methyl-1H-1,2,4-triazol-5-yl)methylene)-4-nitro-, (3Z)-
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[CH2:1]1COCC1.Cl.[F:7][C:8]1[CH:9]=[C:10]([N+:27]([O-:29])=[O:28])[C:11]([C:18](=[O:26])[CH2:19][C:20]2[N:24]=[CH:23][N:22](C)[N:21]=2)=[C:12]([CH:17]=1)[C:13](OC)=[O:14]>CCCCCCC>[F:7][C:8]1[CH:17]=[C:12]2[C:11](/[C:18](=[CH:19]/[C:20]3[N:21]([CH3:1])[N:22]=[CH:23][N:24]=3)/[O:26][C:13]2=[O:14])=[C:10]([N+:27]([O-:29])=[O:28])[CH:9]=1참가 물질
4
실험 절차
An alternative workup procedure to that illustrated in Example 2A follows. Instead of evaporating the reaction mixture to dryness, it was condensed to 2 volumes, followed by solvent exchange with 12 volumes of THF, and then 12 volumes of heptane. The slurry mixture was concentrated to 2 volumes and filtered to give the product. As such, 1.8 kilograms of (Z)-6-fluoro-3-((1-methyl-1H-1,2,4-triazol-3-yl)methylene)-4-nitroisobenzofuran-1(3H)-one (3) gave 2.15 kilograms (yield 96.4%) of the product methyl 5-fluoro-2-(2-(1-methyl-1H-1,2,4-triazole-3-yl)acetyl)-3-nitrobenzoate hydrochloride (4).