Thionyl Chloride → 1-(Benzyloxy)-4-(tert-butyl)-2-(chloromethyl)benzene

HRID 1617291노트

반응식

HRID 1617291 반응식
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:14]([C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:13][C:10]=1[CH2:11]O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O=S(Cl)[Cl:23]>C(Cl)Cl>[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:14]([C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:13][C:10]=1[CH2:11][Cl:23])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 59544156(2-(Benzyloxy)-5-(tert-butyl)phenyl)methanol

생성물 1

HCID 595441551-(Benzyloxy)-4-(tert-butyl)-2-(chloromethyl)benzene

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
20 °C

실험 절차

To a stirred solution of compound 4 (963 g, 3.56 mol) in anhydrous DCM (2000 mL) was added slowly SOCl2 (535 g, 4.5 mol) at 0° C. The mixture was stirred at 20° C. for 2 hours, then concentrated in vacuo to give compound 5 as an oil, which was used in the next reaction without further drying or purification.

후처리

  1. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-f26aba3ac8084c9197c72654b49fd79c
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765957B2

반응 노트

불러오는 중…