4-Bromophenol → 1-Bromo-4-(cyclobutyloxy)benzene
반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[CH:9]1(Br)[CH2:12][CH2:11][CH2:10]1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH:9]2[CH2:12][CH2:11][CH2:10]2)=[CH:4][CH:3]=1참가 물질
6
반응 조건
- 온도
- 120 °C
실험 절차
2.50 g (14.5 mmol) 4-bromophenol, 2.05 mL (21.7 mmol) cyclobutylbromide and 7.99 g (57.8 mmol) K2CO3 are dissolved in 25 mL DMF and stirred at 120° C. for 12 h. Afterwards the reaction mixture is diluted with water and extracted with EtOAc. The organic layer is dried over MgSO4 and the solvent is removed in vacuo. The crude product is used without further purification.
후처리
- extractionextracted with EtOAc
- dry with materialThe organic layer is dried over MgSO4
- customthe solvent is removed in vacuo
- customThe crude product is used without further purification
출처 및 근거
- ORD 기록
- ord-be042042a6fb41c08dbf8cb3c65865e2
- 출처 데이터셋
- uspto-grants-2014_07
- 특허 번호
- US08765959B2
반응 노트
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