Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Iodopyridine → 2-(9H-Fluoren-9-yl)-1-pyridin-4-yl-ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Iodopyridine | HCID 609492 | — |
| 반응물 | 2-(9H-Fluoren-9-yl)-N-methoxy-N-methyl-acetamide | HCID 86660945 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-(9H-Fluoren-9-yl)-1-pyridin-4-yl-ethanone | HCID 66666573 | — |
반응 단계
In analogy to example 55, step 2, from 2-(9H-fluoren-9-yl)-N-methoxy-N-methyl-acetamide and 4-iodopyridine using isopropylmagnesium chloride lithium chloride complex in THF at rt (instead of n-BuLi at −70° C.) was prepared the title compound as yellow oil, MS (ESI+): m/z=286.1 ([M+H]+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08765730B2 |
| 출처 데이터셋 | uspto-grants-2014_07 |
| ORD ID | ord-9b55fd442b5543129a0136d6f4e36a3a |
| 출처 메모 | uspto-grants-2014_07 |