Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-Bromo-2-nitro-1-phenoxybenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Phenol | HCID 996 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 1,4-Dibromo-2-nitrobenzene | HCID 77004 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 4-Bromo-2-nitro-1-phenoxybenzene | HCID 16109449 | 108.8% |
반응 단계
Cs2CO3 (4 g, 12.3 mmol) was added to a solution of phenol (1 g, 10.6 mmol) in 50 mL of THF under N2 atmosphere. After stirring for 15 min. 1,4-dibromo-2-nitrobenzene (2.81 g, 10 mmol) was added. The resulting mixture was heated to reflux and stirred overnight at reflux. Water and ethyl acetate were added, followed by extraction with ethyl acetate (3×). The combined organic layers were washed with water and brine, dried (Na2SO4) and evaporated to give the crude compound (3.2 g, 75%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737136B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-efae84e757614749b3b88bf9a2fe4d09 |
| 출처 메모 | uspto-grants-2010_06 |