Acetic Acid → 6-Bromo-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-2-one

HRID 1618507노트

반응식

HRID 1618507 반응식
[Br:1][C:2]1[CH:3]=[C:4]([N+:15]([O-])=O)[C:5]([C:8]([CH3:14])([CH3:13])[C:9](OC)=[O:10])=[N:6][CH:7]=1.C(O)(=O)C>[Fe]>[Br:1][C:2]1[CH:3]=[C:4]2[NH:15][C:9](=[O:10])[C:8]([CH3:14])([CH3:13])[C:5]2=[N:6][CH:7]=1

참가 물질

4

반응물 2

HCID 176Acetic AcidHCID 672852172-Pyridineacetic acid, 5-bromo-alpha,alpha-dimethyl-3-nitro-, methyl ester

생성물 1

HCID 669587906-Bromo-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-2-one

시약·촉매·용매 1

HCID 23925Iron촉매

반응 조건

온도
100 °C

실험 절차

Prepared according to procedure J using methyl 2-(5-bromo-3-nitropyridin-2-yl)-2-methylpropanoate (0.780 g, 2.57 mmol), acetic acid (14.73 mL, 257 mmol) and iron powder (0.719 g, 12.87 mmol) and heating at 100° C. for 2 h. After purification 6-bromo-3,3-dimethyl-1H-pyrrolo[3,2-b]pyridin-2(3H)-one was obtained as a white solid.

후처리

  1. customPrepared
  2. customAfter purification 6-bromo-3,3-dimethyl-1H-pyrrolo[3,2-b]pyridin-2(3H)-one
  3. customwas obtained as a white solid

출처 및 근거

ORD 기록
ord-e87f604ec1164b59b3319f3a00a54ba3
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765940B2

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