Aniline → HCID 178421928, 화합물

반응식

[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15](=O)[CH:16]([CH3:22])[C:17](OCC)=[O:18]>>[F:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[C:16]([CH3:22])=[C:17]([OH:18])[C:7]2[C:2](=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:1]=1

참가 물질

반응물 2

HCID 6115Aniline

HCID 67285418Ethyl 3-(2-fluorophenyl)-2-methyl-3-oxopropanoate

생성물 1

HCID 178421928HCID 178421928, 화합물

실험 절차

Prepared according to procedure R using aniline (0.91 mL, 10 mmol) and ethyl 3-(2-fluorophenyl)-2-methyl-3-oxopropanoate (4 g, 20 mmol) in PPA (4 g, 40 mmol). The resulting precipitate was collected by filtration, washed with water, and dried to give 2-(2-fluorophenyl)-3-methylquinolin-4-ol. Mass Spectrum (ESI) m/e=254 (M+1).

후처리

customPrepared
filtrationThe resulting precipitate was collected by filtration
washwashed with water
customdried

출처 및 근거

ORD 기록: ord-bc77f94f99ef4ca6b437fc506cd0f3cf
출처 데이터셋: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08765940B2

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