3,3-dibromo-6-chloro-1H,2H,3H-pyrrolo(3,2-c)pyridin-2-one → 6-Chloro-1,3-dihydro-2H-pyrrolo[3,2-c]pyridin-2-one
반응식
Br[C:2]1(Br)[C:6]2[CH:7]=[N:8][C:9]([Cl:11])=[CH:10][C:5]=2[NH:4][C:3]1=[O:12]>C(O)(=O)C.CO.[Zn]>[Cl:11][C:9]1[N:8]=[CH:7][C:6]2[CH2:2][C:3](=[O:12])[NH:4][C:5]=2[CH:10]=1참가 물질
5
실험 절차
To a solution of 3,3-dibromo-6-chloro-1,3-dihydro-2H-pyrrolo[3,2-c]pyridin-2-one (preparation 36d, 1.14 g, 3.49 mmol) in acetic acid (35 mL) was added zinc dust (2.23 g, 34.10 mmol) in one portion and the mixture was stirred at room temperature for 50 minutes. The mixture was diluted with methanol and filtered through a fine frit. The filtrate was evaporated under reduced pressure and the residue was purified by flash chromatography (95:5 dichloromethane/methanol) to give the title compound (0.56 g, 91%) as a white solid.
후처리
- filtrationfiltered through a fine frit
- customThe filtrate was evaporated under reduced pressure
- customthe residue was purified by flash chromatography (95:5 dichloromethane/methanol)
출처 및 근거
- ORD 기록
- ord-3399c7da341b47509f28ee7f1629f686
- 출처 데이터셋
- uspto-grants-2014_07
- 특허 번호
- US08772288B2
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