4,5-Dichloro-1,2,3-dithiazol-1-ium chloride → HCID 178497427, 화합물

HRID 1619347노트

반응식

HRID 1619347 반응식
[Cl-].[Cl:2][C:3]1[C:7](Cl)=[S+:6][S:5][N:4]=1.[NH2:9][C:10]1[CH:19]=[C:18]([Br:20])[CH:17]=[CH:16][C:11]=1[C:12]([O:14][CH3:15])=[O:13]>C(Cl)Cl>[Br:20][C:18]1[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[C:10](/[N:9]=[C:7]2\[C:3]([Cl:2])=[N:4][S:5][S:6]\2)[CH:19]=1

참가 물질

4

반응물 2

HCID 110958474,5-Dichloro-1,2,3-dithiazol-1-ium chlorideHCID 17871390Methyl 2-Amino-4-bromobenzoate

생성물 1

HCID 178497427HCID 178497427, 화합물수율 22.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 4,5-dichloro-1,2,3-dithiazol-1-ium chloride (1.9 g, 9.1 mmol) and methyl 2-amino-4-bromobenzoate (1.0 g, 4.3 mmol) in DCM (10 mL) was stirred for 48 h at room temperature. The solvent was evaporated to give the crude compound, which was purified by column chromatography on silica gel to give 350 mg of the desired product. MS (ESI): 367 (MH+).

후처리

  1. customThe solvent was evaporated
  2. customto give the crude compound, which
  3. customwas purified by column chromatography on silica gel

출처 및 근거

ORD 기록
ord-fb010e8b48bd443c8badea90b0521845
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08772301B2

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