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1,3-Dimethyl 2-[(dimethylamino)methylidene]propanedioate → HCID 67257898, 화합물

HRID 1619380
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인쇄 미리보기

반응식

HRID 1619380 반응식
[CH3:1][N:2]([CH:4]=[C:5]([C:10]([O:12][CH3:13])=[O:11])[C:6]([O:8][CH3:9])=[O:7])C.[Br:14][C:15]1[CH:20]=C[N:18]=[C:17](N)[CH:16]=1>CC(O)=O.O>[Br:14][C:15]1[CH:16]=[CH:17][N:18]=[C:1]([NH:2][CH:4]=[C:5]([C:10]([O:12][CH3:13])=[O:11])[C:6]([O:8][CH3:9])=[O:7])[CH:20]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 5936031,3-Dimethyl 2-[(dimethylamino)methylidene]propanedioateHCID 6932822-Amino-4-bromopyridine

생성물 1

HCID 67257898HCID 67257898, 화합물수율 52.7%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매

실험 절차

A solution of dimethyl 2-((dimethylamino)methylene)malonate (11.5 g, 65 mmol, 2.2 equiv) and 4-bromopyridin-2-amine (5 g, 28.9 mmol, 1 equiv) in AcOH (40 mL) was stirred at room temperature for 24 h. Then the reaction mixture was diluted with water, filtered, the filter cake was dried to give 4.8 g of the desired product. MS (ESI): 315, 317 (MH+).

후처리

  1. filtrationfiltered
  2. customthe filter cake was dried

출처 및 근거

ORD 기록
ord-69cdfced59f44692aa96bf80d213db13
출처 데이터셋
uspto-grants-2014_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08772301B2

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