홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

4,6-Dichloro-5-methylpyrimidine → 4-Chloro-5-methyl-6-(1-(pyrimidin-2-yl)piperidin-4-yloxy)pyrimidine

HRID 1619443
노트
인쇄 미리보기

반응식

HRID 1619443 반응식
CC(C)([O-])C.[K+].[N:7]1[CH:12]=[CH:11][CH:10]=[N:9][C:8]=1[N:13]1[CH2:18][CH2:17][CH:16]([OH:19])[CH2:15][CH2:14]1.[Cl:20][C:21]1[C:26]([CH3:27])=[C:25](Cl)[N:24]=[CH:23][N:22]=1>C1COCC1>[Cl:20][C:21]1[C:26]([CH3:27])=[C:25]([O:19][CH:16]2[CH2:15][CH2:14][N:13]([C:8]3[N:9]=[CH:10][CH:11]=[CH:12][N:7]=3)[CH2:18][CH2:17]2)[N:24]=[CH:23][N:22]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 8188604,6-Dichloro-5-methylpyrimidineHCID 202340981-(Pyrimidin-2-yl)piperidin-4-olHCID 23665647Potassium tert-butoxide

생성물 1

HCID 866651634-Chloro-5-methyl-6-(1-(pyrimidin-2-yl)piperidin-4-yloxy)pyrimidine수율 3.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
30 °C

실험 절차

Potassium tert-butoxide (2.86 gm, 0.01397 moles) was added to an ice-cold solution of 1-(pyrimidin-2-yl)piperidin-4-ol (2.50 gm, 0.01397 moles) and 4,6-dichloro-5-methylpyrimidine (2.27 mg, 0.01397 moles) in dry THF (15 ml) and the reaction mixture was stirred for 5 hours at 30° C. The reaction mixture was poured into ice cold water, solid precipitated was filtered and dried under vacuum to obtain 140 mg of product.

후처리

  1. additionThe reaction mixture was poured into ice cold water, solid
  2. customprecipitated
  3. filtrationwas filtered
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-52999f5c34234070939fbe00122f346c
출처 데이터셋
uspto-grants-2014_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08772302B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트