Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → (R)-Quinuclidin-3-yl 2-amino-2-phenylacetate dihydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | (R)-quinuclidin-3-yl 2-(tert-butoxycarbonylamino)-2-phenylacetate | HCID 67425060 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (R)-Quinuclidin-3-yl 2-amino-2-phenylacetate dihydrochloride | HCID 67425463 | 100.3% |
반응 단계
To a solution of (R)-quinuclidin-3-yl 2-(tert-butoxycarbonylamino)-2-phenylacetate (C1) (1.25 g, 3.47 mmol) in THF (20 ml), was added 37% hydrogen chloride (2.00 ml, 24.3 mmol) dropwise. The reaction was stirred at RT for 15 hours. The solvent was evaporated to obtain (R)-quinuclidin-3-yl 2-amino-2-phenylacetate dihydrochloride (1.16 g; quantitative yield) as a solid. The compound was used in the next step without any further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08772314B2 |
| 출처 데이터셋 | uspto-grants-2014_07 |
| ORD ID | ord-2cbc7e4218c54fd884a503568f50ac5f |
| 출처 메모 | uspto-grants-2014_07 |