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Phenacyl bromide → HCID 86665836, 화합물

HRID 1619527
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HRID 1619527 반응식
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4].[C:11]([O:15][C:16]([NH:18][CH:19]([C:31]1[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[CH:33][CH:32]=1)[C:20]([O:22][C@@H:23]1[CH:28]2[CH2:29][CH2:30][N:25]([CH2:26][CH2:27]2)[CH2:24]1)=[O:21])=[O:17])([CH3:14])([CH3:13])[CH3:12]>CCOC(C)=O.C(#N)C>[O:4]([CH:3]([CH3:2])[CH3:5])[CH:11]([CH3:13])[CH3:12].[Br-:1].[C:11]([O:15][C:16]([NH:18][CH:19]([C:31]1[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[CH:33][CH:32]=1)[C:20]([O:22][C@@H:23]1[CH:28]2[CH2:27][CH2:26][N+:25]([CH2:2][C:3](=[O:4])[C:5]3[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=3)([CH2:30][CH2:29]2)[CH2:24]1)=[O:21])=[O:17])([CH3:14])([CH3:13])[CH3:12]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 2

HCID 6259Phenacyl bromideHCID 67606948HCID 67606948, 화합물

생성물 2

HCID 7914Diisopropyl EtherHCID 86665836HCID 86665836, 화합물수율 114.8%

시약·촉매·용매 2

HCID 6342Acetonitrile용매HCID 8857Ethyl Acetate용매

실험 절차

2-Bromo-1-phenylethanone (39.3 mg, 0.20 mmol) is added to a solution of (R)-quinuclidin-3-yl 2-(tert-butoxycarbonylamino)-2-(4-methoxyphenyl)acetate (C44) (70.0 mg, 0.18 mmol) in EtOAc (2 ml) and acetonitrile (2 ml). The reaction was stirred at RT for 15 hours, and then the solvent was evaporated and the resulting colorless oil was triturated first with i-Pr2O/EtOAc (10/1) and then with i-Pr2O to obtain (3R)-3-(2-(tert-butoxycarbonylamino)-2-(4-methoxyphenyl)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane bromide (60.9 mg; 58% yield).

후처리

  1. customthe solvent was evaporated
  2. customthe resulting colorless oil was triturated first with i-Pr2O/EtOAc (10/1)

출처 및 근거

ORD 기록
ord-43c63f99130242daba95f61355d7a03e
출처 데이터셋
uspto-grants-2014_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08772314B2

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