HCID 66698120, 화합물 → N-methylpyrrolidine-3-sulfonamide
반응식
[CH3:1][NH:2][S:3]([CH:6]1[CH2:10][CH2:9][N:8](C(OCC2C=CC=CC=2)=O)[CH2:7]1)(=[O:5])=[O:4]>CO.[Pd]>[CH3:1][NH:2][S:3]([CH:6]1[CH2:10][CH2:9][NH:8][CH2:7]1)(=[O:5])=[O:4]참가 물질
4
실험 절차
A mixture of the above benzyl carbamate (173 mg, 0.580 mmol) and 10% Pd on carbon in MeOH (15 mL) was hydrogenated for 24 hrs. The reaction mixture was filtered through celite, the celite pad was washed with MeOH, and the solvent was removed under vacuum to give N-methyl-3-pyrrolidinesulfonamide (92 mg, 97%) which was used in the next step without further purification. 1H NMR (DMSO-d6) δ 6.89 (br s, 1H), 3.62 (qd, J=8.9, 6.3 Hz, 1H), 2.99 (m, 2H), 2.82 (m, 1H), 2.72 (m, 1H), 2.59 (s, 3H), 1.95 (m, 2H).
후처리
- filtrationThe reaction mixture was filtered through celite
- washthe celite pad was washed with MeOH
- customthe solvent was removed under vacuum
출처 및 근거
- ORD 기록
- ord-0e7b1dd3f3d64d15b7152a0321449c19
- 출처 데이터셋
- uspto-grants-2014_07
- 특허 번호
- US08772287B2
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