Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cycloheptylamine → 1-Cycloheptyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cycloheptylamine | HCID 2899 | — |
| 반응물 | Dimethyl itaconate | HCID 69240 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 1-Cycloheptyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester | HCID 66656958 | — |
반응 단계
A solution of dimethyl itaconate (0.5 g, 3.16 mmoles), cycloheptylamine (0.357 g, 3.16 mmoles) in methanol (5 mL) was heated at 85° C. for eighteen hours. The solvent was evaporated in vacuo and the resulting crude product was purified by flash chromatography (hexanes/ethyl acetate 80:20 to 20:80) to give the title compound as a colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737137B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-3d2c5d232e3848caaad5f18d300787d9 |
| 출처 메모 | uspto-grants-2010_06 |