Dimethylformamide → 2-Hydroxy-1-(2-phenyl-benzoxazol-6-yl)-butan-1-one

HRID 1619960노트

반응식

HRID 1619960 반응식
Br[CH:2]([CH2:20][CH3:21])[C:3]([C:5]1[CH:19]=[CH:18][C:8]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[O:11][C:7]=2[CH:6]=1)=[O:4].CN(C=[O:26])C>O>[OH:26][CH:2]([CH2:20][CH3:21])[C:3]([C:5]1[CH:19]=[CH:18][C:8]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[O:11][C:7]=2[CH:6]=1)=[O:4]

참가 물질

4

반응물 2

HCID 6228DimethylformamideHCID 866890652-Bromo-1-(2-phenyl-benzoxazol-6-yl)-butan-1-one

생성물 1

HCID 674627762-Hydroxy-1-(2-phenyl-benzoxazol-6-yl)-butan-1-one

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

200 mg (581 μmol) 2-bromo-1-(2-phenyl-benzoxazol-6-yl)-butan-1-one are combined with 1.2 ml DMF and 0.8 ml of water. The mixture is stirred for 3 h at 100° C. and then separated by RP-HPLC.

후처리

  1. customseparated by RP-HPLC

출처 및 근거

ORD 기록
ord-e6240a30b7d64f7c91f09afb6e82a958
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08772323B2

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