Methanol → 3-Bromo-2-methoxy-5-nitropyridine

HRID 1620102노트

반응식

HRID 1620102 반응식
[CH3:1][O-:2].[Na+].CO.[Br:6][C:7]1[C:8](Cl)=[N:9][CH:10]=[C:11]([N+:13]([O-:15])=[O:14])[CH:12]=1>O>[Br:6][C:7]1[C:8]([O:2][CH3:1])=[N:9][CH:10]=[C:11]([N+:13]([O-:15])=[O:14])[CH:12]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 2308893-Bromo-2-chloro-5-nitropyridineHCID 10942334Sodium Methoxide

생성물 1

HCID 215844513-Bromo-2-methoxy-5-nitropyridine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Sodium methoxide (28% methanol solution) (2 ml) was added to a methanol (2 ml) solution containing 3-bromo-2-chloro-5-nitropyridine (100 mg), followed by stirring at room temperature for 1 hour. Water was added to the reaction solution, followed by extraction with ethyl acetate. The resultant was washed with saturated saline and dried over anhydrous sodium sulfate, the solvent was distilled away under reduced pressure, and a yellow solid of 3-bromo-2-methoxy-5-nitropyridine (96 mg) was thus obtained.

후처리

  1. extractionfollowed by extraction with ethyl acetate
  2. washThe resultant was washed with saturated saline
  3. dry with materialdried over anhydrous sodium sulfate
  4. distillationthe solvent was distilled away under reduced pressure

출처 및 근거

ORD 기록
ord-06f9c9a52fc6457d8c66c3707e9dcc82
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08772320B2

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