Hydrogen chloride-ethyl acetate → HCID 178482469, 화합물

HRID 1620468노트

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HRID 1620468 반응식
[CH3:1][NH:2][C:3]1=[N:4][C:5](=[O:22])[S:6]/[C:7]/1=[CH:8]\[CH:9]1[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]1.[ClH:23].C(OCC)(=O)C>O1CCCC1.CO>[ClH:23].[ClH:23].[CH3:1][NH:2][C:3]1=[N:4][C:5](=[O:22])[S:6]/[C:7]/1=[CH:8]\[CH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1

참가 물질

4

반응물 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178482474HCID 178482474, 화합물

생성물 1

HCID 178482469HCID 178482469, 화합물

시약·촉매·용매 1

HCID 21899815MeOH tetrahydrofuran용매

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온도
80 °C

실험 절차

To a solution of tert-butyl 4-{(Z)-[4-(methylamino)-2-oxo-1,3-thiazol-5(2H)-ylidene]methyl}piperidine-1-carboxylate (1.27 g) in tetrahydrofuran/methanol (6 mL/6 mL) was added 4M hydrogen chloride/ethyl acetate solution (5.85 mL), and the reaction mixture was stirred at 80° C. for 2 hr. The solvent was evaporated under reduced pressure, and the residue was washed with ethyl acetate to give the title compound (1.02 g).

후처리

  1. customThe solvent was evaporated under reduced pressure
  2. washthe residue was washed with ethyl acetate

출처 및 근거

ORD 기록
ord-3ee7f2a319124748babbb23808b54c5c
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08772277B2

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