p-Toluenesulfonic acid monohydrate → 1-[2,4-Bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde tosylate

HRID 1620492노트

반응식

HRID 1620492 반응식
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:15]=[CH:14][C:4]=1[CH2:5][N:6]1[CH2:11][CH2:10][CH:9]([CH:12]=[O:13])[CH2:8][CH2:7]1.O.[C:25]1([CH3:35])[CH:30]=[CH:29][C:28]([S:31]([OH:34])(=[O:33])=[O:32])=[CH:27][CH:26]=1>C1(C)C=CC=CC=1>[S:31]([C:28]1[CH:29]=[CH:30][C:25]([CH3:35])=[CH:26][CH:27]=1)([OH:34])(=[O:33])=[O:32].[F:23][C:2]([F:1])([F:22])[C:3]1[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:15]=[CH:14][C:4]=1[CH2:5][N:6]1[CH2:11][CH2:10][CH:9]([CH:12]=[O:13])[CH2:8][CH2:7]1

참가 물질

4

반응물 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 866786631-[2,4-Bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde

생성물 1

HCID 866786841-[2,4-Bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde tosylate수율 95.5%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a solution of 1-[2,4-bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde (170 mg) in toluene (2 mL) was added p-toluenesulfonic acid monohydrate (95 mg), and the mixture was stirred at room temperature for 2 hr. The solvent was evaporated under reduced pressure, and the residue was washed with ethyl acetate. The obtained solid was dried at 60° C. under reduced pressure to give the title compound (244 mg).

후처리

  1. customThe solvent was evaporated under reduced pressure
  2. washthe residue was washed with ethyl acetate
  3. customThe obtained solid was dried at 60° C. under reduced pressure

출처 및 근거

ORD 기록
ord-0a7ee7149e3d424690dc321f91ccbc96
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08772277B2

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