Hydrogen chloride-ethyl acetate → HCID 178456897, 화합물

HRID 1620499

반응식

HRID 1620499 반응식
[O:1]=[C:2]1[N:6]=[C:5]([NH:7][CH2:8][C:9]#[CH:10])/[C:4](=[CH:11]/[CH:12]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)/[S:3]1.[ClH:25].C(OCC)(=O)C>>[ClH:25].[ClH:25].[NH:15]1[CH2:16][CH2:17][CH:12](/[CH:11]=[C:4]2/[C:5]([NH:7][CH2:8][C:9]#[CH:10])=[N:6][C:2](=[O:1])[S:3]/2)[CH2:13][CH2:14]1

참가 물질

3

반응물 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178456946HCID 178456946, 화합물

생성물 1

HCID 178456897HCID 178456897, 화합물

실험 절차

A mixed solution of tert-butyl 4-{(Z)-[2-oxo-4-(prop-2-yn-1-ylamino)-1,3-thiazol-5(2H)-ylidene]methyl}piperidine-1-carboxylate (14.0 g) and 4M hydrogen chloride/ethyl acetate solution (80 mL) was stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure. The residue was washed with ethyl acetate to give the title compound (12.7 g).

후처리

  1. customthe solvent was evaporated under reduced pressure
  2. washThe residue was washed with ethyl acetate

출처 및 근거

ORD 기록
ord-70343f03bc6e4b52a2f38fb43b3958f6
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08772277B2

연결된 노트

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