Fumaric Acid → HCID 178482471, 화합물

HRID 1620520노트

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HRID 1620520 반응식
[F:1][C:2]([F:30])([F:29])[C:3]1[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[CH:21][C:4]=1[CH2:5][N:6]1[CH2:11][CH2:10][CH:9](/[CH:12]=[C:13]2/[C:14]([NH:19][CH3:20])=[N:15][C:16](=[O:18])[S:17]/2)[CH2:8][CH2:7]1.[C:31]([OH:38])(=[O:37])/[CH:32]=[CH:33]/[C:34]([OH:36])=[O:35]>C(O)C>[C:31]([OH:38])(=[O:37])/[CH:32]=[CH:33]/[C:34]([OH:36])=[O:35].[F:30][C:2]([F:1])([F:29])[C:3]1[CH:24]=[C:23]([C:25]([F:27])([F:28])[F:26])[CH:22]=[CH:21][C:4]=1[CH2:5][N:6]1[CH2:11][CH2:10][CH:9](/[CH:12]=[C:13]2/[C:14]([NH:19][CH3:20])=[N:15][C:16](=[O:18])[S:17]/2)[CH2:8][CH2:7]1

참가 물질

4

반응물 2

HCID 444972Fumaric AcidHCID 178482470HCID 178482470, 화합물

생성물 1

HCID 178482471HCID 178482471, 화합물수율 68.8%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

To a solution of (5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-4-(methylamino)-1,3-thiazol-2(5H)-one (765 mg) in ethanol (15 mL) was added a solution of fumaric acid (197 mg) in ethanol (45 mL). The reaction mixture was stirred at room temperature for 1 hr, the solvent was evaporated under reduced pressure, and the residue was washed with ethyl acetate. The obtained powder was recrystallized from ethanol/heptane to give the title compound (662 mg).

후처리

  1. customthe solvent was evaporated under reduced pressure
  2. washthe residue was washed with ethyl acetate
  3. customThe obtained powder was recrystallized from ethanol/heptane

출처 및 근거

ORD 기록
ord-19bd6cf1c467445dbf92355161e552ef
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08772277B2

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