Ammonium Chloride → HCID 178525867, 화합물

HRID 1620607노트

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HRID 1620607 반응식
[F:1][C:2]([F:37])([F:36])[C:3]1[CH:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:29]=[CH:28][C:4]=1[CH2:5][N:6]1[CH2:11][CH2:10][CH:9](/[CH:12]=[C:13]2/[C:14]([NH:19][CH2:20][C:21]([O:23]C(C)(C)C)=[O:22])=[N:15][C:16](=[O:18])[S:17]/2)[CH2:8][CH2:7]1.C(=O)([O-])O.[Na+].[Cl-].[NH4+]>Cl.C(OCC)(=O)C>[F:37][C:2]([F:1])([F:36])[C:3]1[CH:31]=[C:30]([C:32]([F:34])([F:35])[F:33])[CH:29]=[CH:28][C:4]=1[CH2:5][N:6]1[CH2:7][CH2:8][CH:9](/[CH:12]=[C:13]2/[C:14]([NH:19][CH2:20][C:21]([OH:23])=[O:22])=[N:15][C:16](=[O:18])[S:17]/2)[CH2:10][CH2:11]1

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 516892Sodium BicarbonateHCID 178451231HCID 178451231, 화합물

생성물 1

HCID 178525867HCID 178525867, 화합물수율 69.6%

시약·촉매·용매 1

HCID 21866389Hydrogen chloride-ethyl acetate용매

실험 절차

A reaction mixture of tert-butyl N-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]glycinate (4.8 g) and 4N hydrogen chloride/ethyl acetate (20 mL) was stirred at room temperature for 2 hr. To the reaction mixture were added saturated aqueous sodium hydrogen carbonate solution and saturated aqueous ammonium chloride solution, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/methanol) and recrystallized from methanol/ethyl acetate to give the title compound (3.00 g).

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe extract was washed with saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customthe solvent was evaporated under reduced pressure
  5. customThe residue was purified by silica gel column chromatography (ethyl acetate/methanol)
  6. customrecrystallized from methanol/ethyl acetate

출처 및 근거

ORD 기록
ord-30d2119fba5846828a83bad133e4e64d
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08772277B2

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