4-Sulfanylidene-1,3-thiazolidin-2-one → HCID 178496742, 화합물

HRID 1620713노트

반응식

HRID 1620713 반응식
[CH3:1][N:2]([CH3:11])[C:3](=[O:10])[C@H:4]([C@@H:6]([CH3:9])[O:7][CH3:8])[NH2:5].S=[C:13]1[CH2:17][S:16][C:15](=[O:18])[NH:14]1>C(O)C>[CH3:11][N:2]([CH3:1])[C:3](=[O:10])[C@H:4]([C@@H:6]([CH3:9])[O:7][CH3:8])[NH:5][C:13]1[CH2:17][S:16][C:15](=[O:18])[N:14]=1

참가 물질

4

반응물 2

HCID 15395954-Sulfanylidene-1,3-thiazolidin-2-oneHCID 86678876(2S,3R)-2-amino-3-methoxy-N,N-dimethyl-butanamide

생성물 1

HCID 178496742HCID 178496742, 화합물수율 35.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of N,N,O-trimethyl-L-threoninamide (1198 mg) in ethanol (10 mL) was added 4-thioxothiazolidin-2-one (996 mg) at room temperature. The reaction mixture was stirred at room temperature overnight, the solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane) to give the title compound (680 mg).

후처리

  1. customthe solvent was evaporated under reduced pressure
  2. customthe residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-d7bce9d44053494ab92402ebe4a71ecc
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08772277B2

반응 노트

불러오는 중…