4-Sulfanylidene-1,3-thiazolidin-2-one → HCID 178518185, 화합물

HRID 1620724노트

반응식

HRID 1620724 반응식
[NH2:1][C@H:2]1[C@H:7]([OH:8])[CH2:6][O:5][CH2:4][CH2:3]1.S=[C:10]1[CH2:14][S:13][C:12](=[O:15])[NH:11]1>C(O)C>[O:15]=[C:12]1[N:11]=[C:10]([NH:1][C@H:2]2[C@H:7]([OH:8])[CH2:6][O:5][CH2:4][CH2:3]2)[CH2:14][S:13]1

참가 물질

4

반응물 2

HCID 15395954-Sulfanylidene-1,3-thiazolidin-2-oneHCID 54857363trans-4-Aminotetrahydropyran-3-ol

생성물 1

HCID 178518185HCID 178518185, 화합물수율 40%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 3-amino-1,5-anhydro-2,3-dideoxy-threo-pentitol (3.20 g) in ethanol (100 mL) was added 4-thioxo-1,3-thiazolidin-2-one (3.63 g), and the mixture was heated under reflux overnight. The reaction mixture was filtered, the filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to give the title compound (2.36 g).

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux overnight
  3. filtrationThe reaction mixture was filtered
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. customthe residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether)

출처 및 근거

ORD 기록
ord-69d1c4dd78ae46ef89d5de3501e7aa93
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08772277B2

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