참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Toluene-p-sulphonic anhydride | HCID 77773 | — |
| 반응물 | Phenylmethyl (3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxybutanoate | HCID 10040985 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | 1,1-Dichloroethane | HCID 6365 | — |
| 생성물 | (S)-Benzyl 2-(2-oxooxazolidin-4-YL)acetate | HCID 11241814 | — |
반응 단계
To a solution of the alcohol (95.7 g) from Step 1 in dichloroethane (925 mL) was added pyridine (625 mL) and the mixture was cooled to 0-5° C. Anhydrous p-toluenesulfonic anhydride (105.7 g) was added and the mixture was warmed to room temperature and stirred for 1 hour and then heated to 90° C. for 2 hours. The mixture was cooled, diluted with dichloromethane (1000 mL) and washed with 1N HCl (3×600 mL). The organic layer was washed with brine, dried with sodium sulfate and the solvents were removed in vacuo. The residue was purified by chromatography on SiO2 using ethyl acetate and hexanes in a 1:1 ratio followed by ethyl acetate to yield benzyl [(4S)-2-oxo-1,3-oxazolidin-4-yl]acetate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08772336B2 |
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| 출처 데이터셋 | uspto-grants-2014_07 |
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| ORD ID | ord-25a323c1ce15472a9ecd621f28137146 |
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| 출처 메모 | uspto-grants-2014_07 |
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