Ethanol → 2-(1-Methyl-3-(pyridin-4-yl)-1H-1,2,4-triazol-5-yl)ethanamine

HRID 1621102노트

반응식

HRID 1621102 반응식
[CH3:1][N:2]1[C:6]([CH2:7][CH2:8][N:9]2C(=O)C3C(=CC=CC=3)C2=O)=[N:5][C:4]([C:20]2[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=2)=[N:3]1.CCO>CN>[CH3:1][N:2]1[C:6]([CH2:7][CH2:8][NH2:9])=[N:5][C:4]([C:20]2[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=2)=[N:3]1

참가 물질

4

반응물 2

HCID 702Ethanol2회HCID 712792712-(2-(1-Methyl-3-(pyridin-4-yl)-1H-1,2,4-triazol-5-yl)ethyl)isoindoline-1,3-dione

생성물 1

HCID 712792862-(1-Methyl-3-(pyridin-4-yl)-1H-1,2,4-triazol-5-yl)ethanamine수율 74.2%

시약·촉매·용매 1

HCID 6329Methylamine용매2회

실험 절차

2-(2-(1-Methyl-3-(pyridin-4-yl)-1H-1,2,4-triazol-5-yl)ethyl)isoindoline-1,3-dione (114.9 mg, 345 μmol) was dissolved in methylamine solution in EtOH (3.07 mL, 22.5 mmol) and stirred at RT for 1 h. The reaction mixture was evaporated to give light brown solid. The solid was again dissolved in methylamine solution in EtOH (3.07 mL, 22.5 mmol) and the mixture was heated to 50° C. and stirred for 3 h. All volatiles were removed in vacuo and the residue was suspended in dichloromethane (1.5 mL) and filtered. The filtrate was evaporated to give the product as light yellow solid (81.3 mg (80% purity), 256 μmol, 74.2%) which was used without purification for the next step. MS: M=204.2 (M+H)+

후처리

  1. customThe reaction mixture was evaporated
  2. customto give light brown solid
  3. temperaturethe mixture was heated to 50° C.
  4. stirringstirred for 3 h
  5. customAll volatiles were removed in vacuo
  6. filtrationfiltered
  7. customThe filtrate was evaporated

출처 및 근거

ORD 기록
ord-2aa591603db545b990db7cbae8398156
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08772510B2

반응 노트

불러오는 중…