6-Chloro-2-(trifluoromethyl)pyrimidin-4-amine → 6-(2-Fluoropyridin-3-yl)-2-(trifluoromethyl)pyrimidin-4-amine

HRID 1621376

반응식

HRID 1621376 반응식
[F:1][C:2]1[C:7](B(O)O)=[CH:6][CH:5]=[CH:4][N:3]=1.Cl[C:12]1[N:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[N:15]=[C:14]([NH2:22])[CH:13]=1>>[F:1][C:2]1[C:7]([C:12]2[N:17]=[C:16]([C:18]([F:20])([F:19])[F:21])[N:15]=[C:14]([NH2:22])[CH:13]=2)=[CH:6][CH:5]=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 2452716-Chloro-2-(trifluoromethyl)pyrimidin-4-amineHCID 27832702-Fluoropyridine-3-boronic acid

생성물 1

HCID 665999396-(2-Fluoropyridin-3-yl)-2-(trifluoromethyl)pyrimidin-4-amine

실험 절차

The title compound was prepared in an analogous manner to that described above in Example 4 using 2-fluoropyridin-3-ylboronic acid and 6-chloro-2-(trifluoromethyl)pyrimidin-4-amine (SynChem. Inc., Elk Grove Village, Ill.), and the desired product 6-(2-fluoropyridin-3-yl)-2-(trifluoromethyl)pyrimidin-4-amine was isolated as a white solid (34%). LCMS (API-ES) m/z 259 (M+H)+; 1H NMR (400 MHz, d6-DMSO) δ 8.57 (t, J=8.80 Hz, 1H) 8.38 (d, J=3.91 Hz, 1H) 7.83 (br. s., 2H) 7.46-7.63 (m, 1H) 7.15 (s, 1H).

후처리

  1. customThe title compound was prepared in an analogous manner to that

출처 및 근거

ORD 기록
ord-935bef867de748c9bf110681df07ede1
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08772480B2

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