Chloroacetyl chloride → 2-chloro-N-{2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindolin-4-yl}acetamide

반응식

[CH2:1]([CH3:2])[O:3][c:4]1[cH:5][c:6]([CH:12]([CH2:13][S:14](=[O:15])(=[O:16])[CH3:17])[N:18]2[C:19](=[O:29])[c:20]3[cH:21][cH:22][cH:23][c:24]([NH2:28])[c:25]3[C:26]2=[O:27])[cH:7][cH:8][c:9]1[O:10][CH3:11].[Cl:30][CH2:31][C:32](=[O:33])[Cl:34]>>[CH2:1]([CH3:2])[O:3][c:4]1[cH:5][c:6]([CH:12]([CH2:13][S:14](=[O:15])(=[O:16])[CH3:17])[N:18]2[C:19](=[O:29])[c:20]3[cH:21][cH:22][cH:23][c:24]([NH:28][C:32]([CH2:31][Cl:30])=[O:33])[c:25]3[C:26]2=[O:27])[cH:7][cH:8][c:9]1[O:10][CH3:11]

참가 물질

반응물 2

HCID 6577Chloroacetyl chloride

HCID 98449131H-Isoindole-1,3(2H)-dione, 4-amino-2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-

생성물 1

HCID 187583732-chloro-N-{2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindolin-4-yl}acetamide

출처 및 근거

ORD 기록: ord-475727044ef64248b08658e750aaa810
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

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