m-Chloroperbenzoic acid → N-(3-(2-Methyl-6-(methylsulfinyl)pyrimidin-4-YL)pyrazin-2-YL)-1H-indazol-4-amine

HRID 1621494노트

반응식

HRID 1621494 반응식
[CH3:1][C:2]1[N:7]=[C:6]([C:8]2[C:9]([NH:14][C:15]3[C:16]4[CH:17]=[N:18][NH:19][C:20]=4[CH:21]=[CH:22][CH:23]=3)=[N:10][CH:11]=[CH:12][N:13]=2)[CH:5]=[C:4]([S:24][CH3:25])[N:3]=1.ClC1C=C(C=CC=1)C(OO)=[O:31]>O1CCOCC1>[CH3:1][C:2]1[N:7]=[C:6]([C:8]2[C:9]([NH:14][C:15]3[C:16]4[CH:17]=[N:18][NH:19][C:20]=4[CH:21]=[CH:22][CH:23]=3)=[N:10][CH:11]=[CH:12][N:13]=2)[CH:5]=[C:4]([S:24]([CH3:25])=[O:31])[N:3]=1

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 66612118N-(3-(2-methyl-6-(methylthio)pyrimidin-4-yl)pyrazin-2-yl)-1H-indazol-4-amine

생성물 1

HCID 68516415N-(3-(2-Methyl-6-(methylsulfinyl)pyrimidin-4-YL)pyrazin-2-YL)-1H-indazol-4-amine

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture of N-(3-(2-methyl-6-(methylthio)pyrimidin-4-yl)pyrazin-2-yl)-1H-indazol-4-amine (20 mg, 0.057 mmol) and 3-chloroperoxybenzoic acid (14.82 mg, 0.086 mmol, Aldrich, St. Louis, Mo.—77%) in dioxane (1 mL) was stirred at room temperature for 2 h. LCMS showed no starting material left. The reaction mixture was used for the next step of reaction without purification.

후처리

  1. waitleft
  2. customThe reaction mixture was used for the next step of reaction without purification

출처 및 근거

ORD 기록
ord-4357d67b68b7449bbd0ce4469990b0bf
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08772480B2

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