Diisopropylamine → 5-(Benzyloxy)-2-fluoropyridin-3-ylboronic acid

온도

0 °C

A solution of diisopropylamine (Aldrich) (0.33 mL, 2.16 mmol) in THF (5 mL) was cooled to 0° C. and treated with n-butyllithium (Aldrich) (0.94 mL, 2.36 mmol). The resulting mixture was stirred at 0° C. for 30 min and then cooled to −78° C. 5-(Benzyloxy)-2-fluoropyridine (Aldrich) (0.200 g, 0.982 mmol) in THF (3 mL) was added dropwise and the solution was stirred at −78° C. for 40 min before being treated with triisopropyl borate (Aldrich) (0.50 mL, 2.16 mmol) in THF (2 mL). After the addition, the cooling bath was removed and the reaction mixture slowly warmed up to rt and was stirred for 1 h. The reaction mixture was quenched with 5% NaOH (10 mL). The aqueous layer was separated and acidified to pH 5 using 5N HCl. The resulting mixture was extracted with EtOAc (2×15 mL). The combined organic extracts were dried over MgSO4 and concentrated to give the crude product as yellow solid (0.210 g). m/z (ESI, +ve ion) 248.0 (M+H)+. 1H NMR (300 MHz, d4-MeOH) δ 6.60 (br s., 1H); 6.36 (br. s., 1H); 6.00-6.24 (m, 5H); 3.87 (s, 2H).

1. temperaturecooled to −78° C
2. stirringthe solution was stirred at −78° C. for 40 min
3. additionAfter the addition
4. customthe cooling bath was removed
5. temperaturethe reaction mixture slowly warmed up to rt
6. stirringwas stirred for 1 h
7. customThe reaction mixture was quenched with 5% NaOH (10 mL)
8. customThe aqueous layer was separated
9. extractionThe resulting mixture was extracted with EtOAc (2×15 mL)
10. dry with materialThe combined organic extracts were dried over MgSO4
11. concentrationconcentrated

ORD 기록

ord-0936e6fde033425981cc5f17f56d445e

출처 데이터셋

uspto-grants-2014_07

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08772480B2