3,4-Diaminobenzimidamide hydrochloride → HCID 178511950, 화합물
반응식
C[O:2][C:3]([C:5]1[CH:6]=[C:7]([C:21]2[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:22]=2[O:28]C)[C:8]([O:13]CC2C=CC=CC=2)=[C:9]([CH:11]=O)[CH:10]=1)=[O:4].Cl.[NH2:31][C:32]1[CH:33]=[C:34]([CH:38]=[CH:39][C:40]=1[NH2:41])[C:35]([NH2:37])=[NH:36]>>[C:35]([C:34]1[CH:38]=[CH:39][C:40]2[NH:41][C:11]([C:9]3[CH:10]=[C:5]([C:3]([OH:2])=[O:4])[CH:6]=[C:7]([C:21]4[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:22]=4[OH:28])[C:8]=3[OH:13])=[N:31][C:32]=2[CH:33]=1)(=[NH:36])[NH2:37]참가 물질
3
실험 절차
Proceeding as in Reference 23, but substituting 6-benzyloxy-5′-fluoro-5-formyl-2′-methoxybiphenyl-3-carboxylic acid methyl ester (1.3 g, 3.30 mmol) and 3,4-diaminobenzamidine hydrochloride (0.739 g, 3.96 mmol), gave 5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5′-fluoro-6,2′-dihydroxy-biphenyl-3-carboxylic acid (0.780 g).
출처 및 근거
- ORD 기록
- ord-b398b02ca1f04ae99dfbed1236c74d95
- 출처 데이터셋
- uspto-grants-2014_07
- DOI