참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | 4-Pyrimidinol, 5-methyl- | HCID 205324 | — |
| 생성물 | 4-Chloro-5-methylpyrimidine hydrochloride | HCID 53407931 | — |
반응 단계
A mixture of 5-methyl-3H-pyrimidin-4-one (0.60 g, 3.6 mmol) and phosphorous oxychloride (2.0 mL) was heated at 90° C. for 2.5 h. The mixture was evaporated to dryness under reduced pressure and the resultant solid was purified by sublimation under reduced pressure to furnish the title compound as a white solid. This compound was unstable to air and was used immediately in the next step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08778925B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_07 |
|---|
| ORD ID | ord-5c6992e2e2cc4d99b61018019e5c64be |
|---|
| 출처 메모 | uspto-grants-2014_07 |
|---|
