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Sodium Carbonate → HCID 45275877, 화합물

HRID 1622387
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HRID 1622387 반응식
Cl[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:17])[C:7]=1[N:8]1[CH2:13][CH2:12][CH:11]([C:14]([NH2:16])=[O:15])[CH2:10][CH2:9]1.Cl.Cl.[CH3:20][N:21]([C:23]1[CH:28]=[CH:27][C:26](B(O)O)=[CH:25][N:24]=1)[CH3:22].C(=O)([O-])[O-].[Na+].[Na+]>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C(#N)C>[Cl:17][C:6]1[C:7]([N:8]2[CH2:13][CH2:12][CH:11]([C:14]([NH2:16])=[O:15])[CH2:10][CH2:9]2)=[C:2]([C:26]2[CH:25]=[N:24][C:23]([N:21]([CH3:22])[CH3:20])=[CH:28][CH:27]=2)[CH:3]=[N:4][CH:5]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 10340Sodium CarbonateHCID 28116401-(3,5-Dichloropyridin-4-yl)piperidine-4-carboxamideHCID 441182052-(N,N-Dimethylamino)Pyridine-5-Boronic Acid Dihydrochloride

생성물 1

HCID 45275877HCID 45275877, 화합물

시약·촉매·용매 2

HCID 178418397HCID 178418397, 화합물촉매
HCID 6342
Acetonitrile
용매

실험 절차

General procedure E was followed using 1-(3,5-dichloropyridin-4-yl)piperidine-4-carboxamide 23 (50 mg, 0.18 mmol), 2-(N,N-dimethylamino)pyridine-5-boronic acid 2HCl salt (55 mg, 0.23 mmol), tetrakis(triphenylphosphine)palladium(0) (11 mg, 5 mol %), acetonitrile (2 mL) and 0.5 M sodium carbonate (1.3 mL, 0.66 mmol). The crude product was purified by flash column chromatography on silica gel (CH2Cl2, EtOH, 96:4-82:18, biotage 25+S) followed by preparative tlc (CH2Cl2, MeOH, 9:1) to furnish the title compound as an off white solid (6 mg, 9%), LC-MS (ESI, 4 min) Rt 1.28 min, m/z 360 (100%, [M+H]+); m/z (ESI) C17H22N5OCl requires 359.1513, found [M+H]+ 359.1511.

후처리

  1. customThe crude product was purified by flash column chromatography on silica gel (CH2Cl2, EtOH, 96:4-82:18, biotage 25+S)

출처 및 근거

ORD 기록
ord-b427c723741142ebb0c5764a48214c45
출처 데이터셋
uspto-grants-2014_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08778925B2

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