Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl diazoacetate → 4-(Tert-butyl-diphenyl-silanyloxy)-bicyclo[5.1.0]octane-8-carboxylic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl diazoacetate | HCID 12192 | — |
| 반응물 | Tert-butyl-(cyclohept-4-enyloxy)-diphenyl-silane | HCID 67512396 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-(Tert-butyl-diphenyl-silanyloxy)-bicyclo[5.1.0]octane-8-carboxylic acid ethyl ester | HCID 68688603 | — |
반응 단계
To a solution of Example 8C (2.2 g, 6.28 mmoles) and Rh2(OAc)4 (2 mg, 4.3 μmol) in dichloromethane (2 mL), ethyl diazoacetate (0.717 g, 6.28 mmoles) in dichloromethane (4 mL) was added over two hours via a syringe pump. The solvent was evaporated in vacuo and product purified by flash column chromatography (hexanes:ethyl acetate 100:0 to 80:20) to provide the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737137B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-e40caf334b0742ffaf4ef4909375fc79 |
| 출처 메모 | uspto-grants-2010_06 |