Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → 3-(4-((Tert-butyl(dimethyl)silyl)oxy)phenyl)pyridin-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| 반응물 | 4-(2-Aminopyridin-3-yl)phenol | HCID 66748477 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-(4-((Tert-butyl(dimethyl)silyl)oxy)phenyl)pyridin-2-amine | HCID 66747707 | — |
반응 단계
A mixture of 4-(2-aminopyridin-3-yl)phenol (19.8 g), tert-butyldimethylchlorosilane (21.8 mL) and 1H-imidazol (8.69 g) in DMF (200 mL) was stirred at room temperature for 20 hr. To the mixture was added water, and the resulting precipitate was collected by filtration, and then washed with water to give the title compound (30.5 g) as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08778934B2 |
| 출처 데이터셋 | uspto-grants-2014_07 |
| ORD ID | ord-4fbeb80586f945ee99656b49ed57d9e2 |
| 출처 메모 | uspto-grants-2014_07 |