Hydrogen Peroxide → 5-amino-1-cyclopentyl-1H-pyrazole-4-carboxamide

HRID 16233

반응식

HRID 16233 반응식
[OH:1]O.[NH2:3][C:4]1[N:8]([CH:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)[N:7]=[CH:6][C:5]=1[C:14]#[N:15]>C(O)C.N>[NH2:3][C:4]1[N:8]([CH:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)[N:7]=[CH:6][C:5]=1[C:14]([NH2:15])=[O:1]

참가 물질

5

반응물 2

HCID 784Hydrogen PeroxideHCID 179603715-Amino-1-cyclopentyl-1H-pyrazole-4-carbonitrile

생성물 1

HCID 117011915-amino-1-cyclopentyl-1H-pyrazole-4-carboxamide

시약·촉매·용매 2

HCID 222Ammonia용매HCID 702Ethanol용매

실험 절차

85 ml of 30% strength hydrogen peroxide solution are added to a solution of 5-amino-1-cyclopentyl-1H-pyrazole-4-carbonitrile (6.74 g, 38.3 mmol) in a mixture of 300 ml of ethanol and 371 ml of concentrated aqueous ammonia solution at room temperature and stirred at room temperature overnight. The nonaqueous solvents are then stripped off in a rotary evaporator. The product precipitates as solid from the remaining mixture and is filtered off with suction, washed with diethyl ether and dried under high vacuum.

후처리

  1. customThe nonaqueous solvents are then stripped off in a rotary evaporator
  2. customThe product precipitates as solid from the remaining mixture
  3. filtrationis filtered off with suction
  4. washwashed with diethyl ether
  5. customdried under high vacuum

출처 및 근거

ORD 기록
ord-892422c49c6a4ab68cb6f1424c4c75ad
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737156B2

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