4-Toluenesulfonyl chloride → Methyl 2-hydroxy-5-{[(4-methylphenyl)sulfonyl]oxy}benzoate

HRID 1623656노트

반응식

HRID 1623656 반응식
[OH:1][C:2]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].C(=O)([O-])[O-].[K+].[K+].[S:19](Cl)([C:22]1[CH:28]=[CH:27][C:25]([CH3:26])=[CH:24][CH:23]=1)(=[O:21])=[O:20]>CC(C)=O>[OH:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][S:19]([C:22]2[CH:28]=[CH:27][C:25]([CH3:26])=[CH:24][CH:23]=2)(=[O:21])=[O:20])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]

참가 물질

5

반응물 3

HCID 73974-Toluenesulfonyl chlorideHCID 11430Potassium CarbonateHCID 75077Methyl Gentisate

생성물 1

HCID 15727852Methyl 2-hydroxy-5-{[(4-methylphenyl)sulfonyl]oxy}benzoate

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of methyl 2,5-dihydroxybenzoate (1.5 g, 8.92 mmol), potassium carbonate (7.50 g, 54.2 mmol), and dry acetone (100 ml) was stirred at room temperature for 30 min. To the mixture was added TsCl (1.72 g, 9.00 mmol) portionwise and the mixture was refluxed for 7 h. The reaction mixture was used in the next step directly.

후처리

  1. temperaturethe mixture was refluxed for 7 h

출처 및 근거

ORD 기록
ord-84de467f8d274fb9b3a510b96ab648b3
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08778939B2

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