Benzyl Bromide → Methyl 5-{[(4-methylphenyl)sulfonyl]oxy}-2-[(phenylmethyl)oxy]benzoate

HRID 1623657노트

반응식

HRID 1623657 반응식
Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[OH:9][C:10]1[CH:19]=[CH:18][C:17]([O:20][S:21]([C:24]2[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][CH:25]=2)(=[O:23])=[O:22])=[CH:16][C:11]=1[C:12]([O:14][CH3:15])=[O:13]>>[CH3:30][C:27]1[CH:28]=[CH:29][C:24]([S:21]([O:20][C:17]2[CH:18]=[CH:19][C:10]([O:9][CH2:2][C:3]3[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=3)=[C:11]([CH:16]=2)[C:12]([O:14][CH3:15])=[O:13])(=[O:23])=[O:22])=[CH:25][CH:26]=1

참가 물질

3

반응물 2

HCID 7498Benzyl BromideHCID 15727852Methyl 2-hydroxy-5-{[(4-methylphenyl)sulfonyl]oxy}benzoate

생성물 1

HCID 86762539Methyl 5-{[(4-methylphenyl)sulfonyl]oxy}-2-[(phenylmethyl)oxy]benzoate

실험 절차

(Bromomethyl)benzene (3.81 g, 22.26 mmol) was added to methyl 2-hydroxy-5-{[(4-methylphenyl)sulfonyl]oxy}benzoate (may be prepared as described in Description 36; 2.87 g, 8.90 mmol) and the resulting mixture was refluxed overnight. After cooling, the resulting precipitate was filtered and the filtrate was evaporated. The crude product was purified by silica gel chromatography, eluting with a 4:1 mixture of hexane:ethyl acetate to yield the title compound as a colourless oil. 2.7 g.

후처리

  1. temperaturethe resulting mixture was refluxed overnight
  2. temperatureAfter cooling
  3. filtrationthe resulting precipitate was filtered
  4. customthe filtrate was evaporated
  5. customThe crude product was purified by silica gel chromatography
  6. washeluting with a 4:1 mixture of hexane

출처 및 근거

ORD 기록
ord-d37e0a2dd1dd45afb5713aa859ab0eda
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08778939B2

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