Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 16237생성일: 2026년 10월 25일
Methyl iodide → 6-((2-chloropyrimidin-4-yl)(methyl)amino)-N,2-dimethylbenzofuran-3-carboxamide
https://huagongshe.com/reaction/16237
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 6-(2-chloropyrimidin-4-ylamino)-N,2-dimethylbenzofuran-3-carboxamide | HCID 59224746 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 6-((2-chloropyrimidin-4-yl)(methyl)amino)-N,2-dimethylbenzofuran-3-carboxamide | HCID 59224747 | 22% |
반응 단계
Potassium carbonate (0.75 mmol) was added to a solution of 6-(2-chloropyrimidin-4-ylamino)-N,2-dimethylbenzofuran-3-carboxamide (0.5 mmol) in 5 ml acetone. After 15 mins, methyl iodide (0.5 mmol) was added. The reaction mixture was stirred at 60° C. for 2 days before the solvent was removed in vacuo. THF was added and the residue was filtered and subjected to column chromatography to provide the 6-((2-chloropyrimidin-4-yl)(methyl)amino)-N,2-dimethylbenzofuran-3-carboxamide in a yield of 22%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07737157B2 |
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| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-b08622b8d24847d484b646a4b84e3bf4 |
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| 출처 메모 | uspto-grants-2010_06 |
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